Ethyl ester of 8-methoxy-2-phenylquinolin-4-carboxylic acid.



Uni-ran STATES;

FATENT UFFICE.

MAX D OHRlST, OF BERLIN, GER-MANY, ASSIGNOR- TO CHEMISCHE FABBIK AUF ACTIEN (VORM. E. SCHERING). GE BERLIN. GERMANY.

ETHYL ESTER OF S-METHOXY-Q-FF No Drawing.

To all 2 3 mm it may concern.

1 Be it known that I. )L-ix Donna, doctor of philosophy. chemist. citizen of the German Empire. residing at Berlin. Germany, have invented a new and useful Improvement in Ethyl Esters of S-Methoxy-Q- Phenylquinolin-sl-Carboxylic Acid, of which the t'ellowing a specification. I

This invention relates to the manufacture of the ethyl ester of S-methoxy-Q-phenylquinolin-l-carboxylic acid, which is useful in the treatment of gout and articular rheumatism. Theester has the following constitution:

. cooczn5 (lea. l: It forms pale yellow colored crystals and melts at about 109 C. and is soluble in alcohol, ether and benzene and forms salts with .acids.

Specification of Letters Patent.

Atiplication filed J 11118 15, 1912. Serial No. 703,812.

Y1.QUINOLEIJ-ei-CARBOXYLIG ACID.

Patented Nov. 26, 1912.

The new product may be obtained by esteritication of the S-methoxy-Q-phenylquinclin-l-carhottylic acid. for instance in the following way: Dry hydrochloric acid gas is passed for some hours through an ethylalcoholic solution of S-methoxy-Q-phenylquinolin-lcarboxylic acid saturated in the cold with hydrochloric acid. The solution precipitated with water. extracted with ether and the residuum of the ethereal solution recrystallized from alcohol.

I claim as my invention:

The herein described ethyl ester of 8- methoxyQ-phenylquinolin-l-carboxylic acid, melting at about 109 (1.. forming pale yellow colored crystals, being soluble in alcohol, ether and benzene. and forming salts, substantially as described.

In testimony whereof I have hereunto set my hand in the presence of two subscribing witnesses.

MAX DOHRN. \Vitnesses:

HENRY HASPER, YVOL'DEMAR HAUPT. 

